I know of several 30-06 shooters that in seeking a downloaded cartridge, blew chambers. The case capacity and low volume of powder resulted in not a sqib load, but rather, complete detonation. Destroying the rifle.
Same can happen with a shotgun.
So, my belief is this.
Stick to published data.
I cringe when I read about handloaders toying with untested recipes.
As to mistakenly loading a shell or two with the wrong powder, What happens when you pop off the powder bottle and switch powders on a Mec? Is any left in the bar?
If there is, then both the variety, and quantity of powder could be wrong for the next shell.
I am not near my reloaders to see, so someone please see if this last idea is true.
