Some of these newer rounds are going away such as the 480 Ruger.To many new rounds show little real difference to the old ones except when reloading and most don't.I would take the 22-250 over the 223 because it can do more.One of my favorits out to two hundred yards on small stuff is the 22Hornet,very cheap to reload.The 25-06 is about right there with the 264 win and in a pinch with the right bullet could turn out the lights of anything walking.Companies go with the masses and the masses say cheap hence the 223 takeing over the 22-250,not cause its better or equal but dollars.JMHO