Lived in Buffalo for a bit, glad to be gone (7/20/09). Worst city I have lived in, and I am counting 2 3rd world countries on the list.

The falls are a bit north(ish) worth a trip if you have time. Ft Niagara is nice too. Niagara Falls the city is a tourist hell hole, depressed and ugly.
Buffalo Gun Center has a lot of guns, not many of note as I recall but many.
Harry's on the Harbor has a great lunch and supper. Bananas Foster on the menu.