Good call Kieth, when I loaded for buffalo shooting, the weather was very fair most of the time. However the summers here in Iowa tend to get VERY HUMID. This humidity most often led to a least one "hang fire" at a weekend match. I know from expirience with the "duplex" loads that ignition is more reliable, but the moisture in hunting situations is usually far greater. I think reading that now would steer me away from a duplex load for hunting.
On a side note: has anyone ever loaded shotshells with IMR Trailboss? I works excellent in all the "old" cowboy arms that require less pressure. They say "fill the case and shoot" It is so bulky that you can't overcharge in cases like 45/70 and the like. I have had great results with it in traditional "black powder cartridges" There is some velocity loss, but that's no big deal to me. I enjoy shooting my old lever guns, falling blocks, and Colt SAA's. Now it seems the perfect avenue for older doubles for target loads. I know I can buy things like RST but I enjoy loading my own shells if for no other reason than to pass the wickedly cold winter after the hunting season closes.