Ross Seyfried advised me to avoid compressed loads with Trailboss as it's pressure behaviour may be erratic. He agrees that filling the case otherwise is not a problem.
A reduced load for target work would be welcome, expecially in my carbine, and especially if the impact point at 100 yds is lowered.
Barnes makes some lead free 45 cal bullets that could be patched up, like their .451 Expander in 300 gr. Are you working along those lines?
http://www.barnesbullets.com/products/muzzleloader/expander-mz/