Even though the vaccine is Western Diamondback specific it is my understanding that there is some spillover in protection to the other snakes. This includes Copperheads and the other rattlesnake varieties with the exception of the Mojave rattler. I know some Vets that ARE big believers in the vaccine having treated multiple dogs with and without prior vaccination. To me, anyway, if there is a chance it helps and with the cost pretty minimal, why not?? Very cheap insurance in my opinion. None of my dogs have had any adverse reactions other than an occasional slight swelling at the injection site.