I spend a month in Alaska every year fishing for the Rainbow trout that feed on the eggs and flesh of the returning salmon. On a daily basis there will be Brown bears up close and personal, feeding on the waning salmon.
I load my own 45 Long Colt bear loads and the revolver gets submerged or at least wet on a daily basis, as do the bullets.
I apply clear nail polish(one could use a color I suppose) to the primers. I need to have full confidence these will perform properly if needed. Never (yet) have I had any type of misfire or squib. I test the loads regularly and have been doing this more than 5 years.
I believe one could apply polish to both the primer and the crimp and be quite certain that moisture would not reach the powder.