Scroll down about 1/3 here for details of Bell's study
https://docs.google.com/document/d/1ZIo0y746UsSRZIgRuuxwAbZjSBHitO_EanvwLYc-kGA/edit Bottom line: Shooting 2 3/4 shells in 2 1/2 chambers does make them produce more pressure-but in most cases it is less than a 1000 psi increase. I see no reason, related to safety, to modify an original 2 1/2 chambered gun to shoot 2 3/4 shells, if the 2 3/4 load you intend to use would develop pressure that is safe in that gun, when fired in a standard chamber!
Depending on the gun and barrels, 1000 psi may matter however.