As found through the Hodgdon tool, I was pursuing 18.8gn of Clays. This should have resulted in 5200psi, 1200fps with a 7/8oz load and the CD-4100-12 wad. The bushing used was a #33, which MEC's chart states yields 18.6gn of Clays. I measured this 10 times before I started reloading, and they were consistently within .3gn of the target.

I disassembled five shells last night, and found the following:
7/8oz charge bar, #8 = .875oz - .888oz
19.2gn - 19.7gn

I suppose the powder settled a good bit, because the bushing tested right at the beginning.

If I match up what I discovered by dissecting, then I have something very close to the next load up in power with these same components, which would be 6100psi, and 1250fps.

Is 6100psi and 1250fps considered too stout for damascus/twist barreled guns in good sound condition? I would think it is not, even if it's not pleasant to shoot.