I have a Remington model 30 Express that I've owned for 40+ years. It started off as a 30-06 and I used it for a number of years in that configuration. About 30 years ago when I lived in AK, I decided to re-barrel to a 35 Whelan AI stainless and re-stock in a synthetic stock to make it more impervious to weather and salt water spray and more useful IMO for the animals I hunted.
In some ways I wish I wouldn't have messed with it and yes I scoped it without any alteration. It is patterned off the P14/M1917 Enfield action. It's a large action and as far as I know doesn't need a whole lot of alteration to accept some of the very large calibers. I read some time ago that Art Alphin of A-Square used the P14/M1917 actions for many of his proprietary large bore caliber rifles.