But more times than naught my experience has been 1150-1225 seems to be the sweet spot.
Me, too. And, I have another overriding requirement. Because I pattern loads regularly I also see how well my S X Ss are regulated with that load. I have found that in nearly all my vintage S X Ss a slow, but "heavy", load regulates the best. I will not tolerate going to the field with a gun and load that is cross firing by several inches, handicapping me out of the gate. A great example is my Fox Sterlingworth Ejector 20 ga. bird gun. When I got it I wanted to use 7/8 oz. loads at about 1250, over the counter stuff. They cross fired in it by 8" each, at 25 yards. It was determined that all it needed, wanted, to regulate perfectly was 1 oz. loads at 1150. I agree with your comments on pellet size, completely. And, I've never seen where going up or down in pellet size in the same load affected regulation. Velocity and payload sure do, though.