Fitting barrels properly is tedious enough. Making one forend work with two sets of barrels takes that time and skill to the quantum level. 'Smiths who can PROPERLY fit a set of barrels to a doublegun are not on every street corner. Learning that truth was costly for me. It is a skill that I want to learn for myself before leaving this mortal plane. Having tried and failed at it, I am now even more determined.
There was an excellent article in a Shooting Sportsman magazine some years ago, I believe by Vic Venters, that was titled "Jointing on the Circle", AIR. It was by far the best piece on the subject I've ever seen. I have lost track of it, but may just dig through all my old copies, this rainy day, until I find it again. It is well worth the effort.
Even in these days of CNC precision machining, the manufactures of SxS & O/U guns still do a lot of hand fitting to get things just right.
This is just my opinion, for what it's worth, but building a gun that has interchangeable barrel sets is not beyond the capabilities of CNC manufacturing. The Thompson Contender break action is an example, with it's interchangeable barrels in different calibers, and it handles chamber pressures many times higher than any shotgun shell.