Absolutely. The straight grip require that you rotate your thumb up into proximity of your nose, and its necessary to regain some clearance. Single-trigger straight-grip guns are a little more tolerant of length if the trigger has something of a central position within the guard. On two-tirgger guns, no question.
No question in your mind(only). I shoot both types interchangably, PG and straight grip, single trigger and double. All with the same LOP. I know what works for me. IMO, the whole question is just BS to fill up a monthly magazine column, as is the BS about barrel flip with SxS requiring them to have different drops than O/Us, etc. What works for you is surely OK with me. Just don't cite it as constitutional law, any more than my opinions are anything more than just my opinions.