"IF" one is Concerned about a set of barrels with good wall thickness at the breech end but thin at 18+ inches from the breech, shoot the load which gives the highest breech pressure commensurate with the overall desired ballistics.
You may for instance shoot two 1 oz loads which both reach 1200 fps muzzle velocity. If one of those loads has 3K "Less" "MAX Chamber Pressure" than the other, it's going to make it up some where else. I TRULY WONDER just where that might Be.

Miller/TN
I Didn't Say Everything I Said, Yogi Berra