Many years ago, Ed Harris wrote an article entitled " The Load", which works in most mid-capacity cartridges. His load was 13 grains of Red Dot behind most bullets appropriate for the particular cartridge. Many of my contemporaries used 12 grains of Unique in a similar fashion, but I have better results with "The Load". However, I often use a tuft of kapok tamped over the powder and Ed Harris specifically advised against fillers; so while I do it, I'm not recommending doing it.
Mike